7/25/2023 0 Comments Blood viscosity unitsIf the solvent is a thermodynamically ‘good’ solvent for the polymer (polymer-solvent intermolecular forces are strongest), then solvent molecules. In the dilute region, the coils are widely separated and not able to interact hydrodynamically. Our preliminary data thus indicate positive in vitro hemorheological effects of nattokinase, and suggest its potential value as a therapeutic agent and the need for additional studies and clinical trials. Relative viscosity concentration (phase volume) relationship for a polymer in solution. Our in vitro results showed a significant, dose-dependent decrease of RBC aggregation and low-shear viscosity, with these beneficial effects evident at concentrations similar to those achieved in previous in vivo animal trials. In fact, increasing the hematocrit from 40 to 60 (a 50 increase) increases the relative viscosity from 4 to 8 (a 100 increase). Patients with an abnormal elevation in red cell hematocrit (polycythemia) have much higher blood viscosities. RBC aggregation was measured using a Myrenne MA-1 aggregometer and blood viscosity assessed over 1-1000 s(-1) with a computer controlled scanning capillary rheometer (Rheolog). At a normal hematocrit of 40, the relative viscosity of blood is about 4. Blood samples were incubated with nattokinase (final activities of 0, 15.6, 31.3, 62.5 and 125 units/ml) for 30 minutes at 37 degrees C. However, no studies to date have evaluated the effects of nattokinase on various hemorheological parameters and thus we have begun to assess the effects of the enzyme on RBC aggregation and blood viscosity. Ten poise equal one pascal second Pa s making the centipoise cP and millipascal second mPa s identical. The unit of viscosity, accordingly, is newton -second per square metre, which is usually expressed as pascal -second in SI units. ![]() In vitro and in vivo studies have consistently demonstrated the potent pro-fibrinolytic effect of the enzyme. The most common unit of viscosity is the dyne second per square centimeter dyne s/cm 2, which is given the name poise P after the French physiologist Jean Poiseuille (17991869). A fibrinolytic enzyme, termed nattokinase, can be extracted from natto the enzyme is a subtilisin-like serine protease composed of 275 amino acid residues and has a molecular weight of 27.7 kDa. The vegetable cheese-like food, natto, is extremely popular in Japan with a history extending back over 1000 years.
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